UB-UZ HRTP Program Goals

Main Goals:

  1. Train researchers to contribute to the mission of antiretroviral access and optimizing treatment in Zimbabwe through the UZ International Center for HIV/AIDS Pharmacotherapy Research and Training (ICHAPRT) Center in Harare.
  2. Implement and support a long-term plan to provide ongoing research training to UZ faculty of the Pharmacy and Medical School.
  3. Implement and support a long-term plan to provide ongoing research training to UZ pre-doctoral, doctoral and post-doctoral students.
  4. Establish web-based training programs to complement mentored training programs for Zimbabwe and southern African countries to facilitate technology transfer from the UB HIV Pharmacology program.

The UB-UZ HRTP has established a postgraduate fellowship training initiative to conduct HIV/AIDS clinical and translational pharmacology research in Zimbabwe. The University at Buffalo (UB) and University of Zimbabwe (UZ) faculty provide mentored training with a focus on current and investigational drug treatment for HIV/AIDS and tuberculosis and the clinical pharmacology expertise to integrate with multidisciplinary teams to achieve the HIV/AIDS research goals for Zimbabwe and other southern African countries and build research capacity.

Key programmatic themes include pharmacokinetics, pharmacodynamics, pharmacogenomics, pharmacoinformatics and pharmacoeconomics with targeted research training in medication adherence, drug interactions, traditional medicines, bioequivalence testing, integrating therapeutic drug monitoring and viral load/resistance tests and biochemical and clinical adverse effect monitoring. The program utilizes clinical research sites and bioanalytical laboratories to design mentored interactions with faculty and health professionals for HRTP fellows to benefit from established clinical and translational research environments.

The HRTP infrastructure includes collaboration with the UZ International Clinical, Operational, and Health Services Research and Training Award (ICOHRTA), NIH/Division of AIDS (DAIDS)-funded HIV research networks, the UZ Clinical Trials Site, as well as other US-supported and Zimbabwe-based research programs. The approach provides opportunities for HRTP fellows to develop their research career during the HRTP period and then continue in a collaborative, mentored environment after the training period. The HRTP includes a focused didactic curriculum for postgraduate trainees and an integrated research project experience that includes on-site training at UB and UZ.

The HRTP will focus on a group of highly trained individuals who will then pursue their research programs within the multidisciplinary environment that is present at UZ with continued mentoring and career development. Strong institutional support for the proposed HRTP is evident through participation of faculty and administrative leaders at UZ in recognition of the need to support the development of future researchers to address the HIV/AIDS epidemic in Zimbabwe and surrounding regions.

SPECIFIC AIMS:

  1. Conduct HIV/AIDS clinical and translational pharmacology research and mentoring in Zimbabwe and southern African countries with a focus on current and investigational drug treatment for HIV/AIDS and tuberculosis.
  2. Conduct HIV/AIDS clinical and translational pharmacology research and mentoring in key programmatic themes including pharmacokinetics, pharmacodynamics, pharmacogenomics, pharmacoinformatics and pharmacoeconomics with targeted training in medication adherence, drug interactions, traditional medicines, bioequivalence testing, integrating therapeutic drug monitoring and viral load/resistance tests and biochemical and clinical adverse effect monitoring.
  3. Provide a mentored research training environment to establish independent clinical and translational pharmacology investigators and enhance the research capacity of Zimbabwe and surrounding regions.