Transplantation Immunosuppressive Clinical Pharmacology Program

Program Director | Physician Co-Investigator | Publications | Abstract/Presentations | Current Research Programs/ActivitiesResearch Personnel

Dr. Kathleen M. Tornatore, PharmD, FCCP

Program Director

Dr. Tornatore's research focus is in the area of Clinical Pharmacokinetics and Pharmacodynamics of immunosuppressive drugs after renal transplantation. This clinical research program has been an ongoing collaborative program with the UB Department of Medicine, Division of Nephrology, at Erie County Medical Center for over 15 years. Current and planned clinical research projects focus on understanding the relationshiop between the pharmacokinetics of immunosuppressive drugs,  pharmacodynamics of immunologic markers and pharmacogenomic endpoints as related to race and gender of renal transplant recipients. 

Research projects include students and fellows, and provide exposure to a variety of biomedical technologies including mass spectrometry (LCMSMS), flow cytometry and Q-PCR. Projects explore clinical and translational research though a multidisciplinary research team including PharmDs, physicians, nurse clinicians, immunologists, geneticists and biostatisticians. Extensive clinical research has also focused on the pharmacokinetics and pharmacodynamics of glucocorticoids with specific emphasis on the impact of gender, race, acute rejection, time post-transplant, immunologic response and chronic adverse effects in the renal transplant population. The pharmacodynamics of anti-lymphocyte induction agents as well as glucocorticoid pharmacokinetics during various “steroid withdrawal” protocols have also been completed.